CO2 micronization is a process that reduces the size of particles of oily ingredients, such as fats, waxes, and lipids, to a very fine powder to enhance their physical and chemical properties. This technique can improve the solubility, stability, and bioavailability of these ingredients, as well as enhance their sensory properties and functionality.

Separeco method of micronization is using supercritical or near-critical carbon dioxide (CO2) as a solvent and antisolvent. This method is especially suitable for powders of oily ingredients, such as vitamins, antioxidants, and essential oils, because it avoids the use of organic solvents and high temperatures that may degrade the quality of the products. The process involves dissolving the oily ingredients in CO2 at high pressure and temperature, and then spraying the solution into a lower pressure chamber, where the CO2 rapidly expands and forms fine particles of the solute.

Micronization is establishing itself as one of the emerging technologies capable of modifying the biological response to the intake of active ingredients such as medicines in general, antibiotics, etc. well defined with the term bioavailability.

It is easy to find many solutions for the micronization of hydrophilic substances, but very few for lipophilic substances. In fact, until recently, it was possible to simply adsorb oils on maltodextrins or similar material.

Now, the formation of particles in the micrometer and nanometer scale is possible for the most part using the power of CO2

We offer multiple solutions and technologies to produce micronized lipophilic and hydrophilic matrices. Among these are the Near-critical Expansion Atomization (NEA), the Particles From Gas-Saturated Solutions (PGSS) and the Supercritical Anti Solvent (SAS).

We can micronize polymers used for drug delivery, micronize antibiotics, coating with adjuvant substances that can protect the APIs from attacks by gastric juices and promote the absorption of medicinal substances. The formulation of the matrices to be micronized changes upon customer’s needs.