500 mm column Supercritical CO2 Chromatography

Size & Weight

The frame, the vessels and the piping are built with stainless steel, the total structure has the following characteristics:
Width 1.8m (5.9feet), Height 1.6m (5.25feet), Depth 1 m (3.3 feet).
Weight 700kg (1543#).
Minimum Room size 4.8 × 4 m (15.7′ × 13′), Height 2.3 m (7.5′)

Vessels Volume

Separators 1, 2, 3, 4, 5, 6
Volume: 1 L
Waste Separator volume: 1 L
Chromatographic Column: 500mm

System performance

Max pressure: 300 bar
Max temperature: 65° C
Max CO2 flow: 1 kg/h
Max co-solvent flow: 1 kg/h
Max product flow: 20 ml/min

Main Characteristics

It is a preparative system equipped with a 500mm column. It is available with 6 or more separators for the fractionation of the extract. Provided with diaphragm pumps and stainless-steel frame to comply with HACCP and GMP guidelines. Voltage 460V/3ph or 400V/3ph, frequency 60Hz or 50Hz, installed Power 8 kW, Current 13.8 A. PLC on board and 7′′ touch screen.

Certification

Certifications are mandatory for high pressure equipment. This machine is certified PED/CE for Europe, Africa South America and other countries accepting EU regulation or ASME/UL for North America and other countries requesting ASME regulation.
We are ISO 9001 certified by TUV, UL listed, ASME certified, CE and PED certified by Apave, CRN for Canada.

Configuration of supercritical CO2 chromatographer

This machine is designed to work with two or three pumps: one for CO2, one for the product and another one for co-solvent, one chromatographic column, five/six/seven separation vessels and separated chiller and heater. It can reach max pressure (Pmax) of 300 bar and max temperature (Tmax) of 80 °C. There are pressure gauges for all separators and voltage supply can be chosen on request.
Carbon dioxide is continually recycled with a close circuit for fluid recirculation. It’s full automated and process is controlled by on board computer. Automation not only controls pressure and temperature but operates the full extraction process.

Pumps

There are three pumps, the most important is the CO2 pump (the carbon dioxide is the principal solvent), the secondary pump or co-solvent pump, which is used for the contemporary release in the process of polar or medium apolar co-solvents, useful for the extraction of chemical compounds with different degrees of polarity and the third pump used to pump the product. At the condition of max pressure these pumps can ensure a CO2 Flow of 1 kg/h, a co-solvent Flow of 1 kg/h and a product flow of 20ml/min.

Safety

This system can be equipped with a safety certified PLC in addition to process PLC controlling the position of the lids, the position of the valves and other safety sensors assuring safety operations. Improving safety of the operator is our mission.

Other specifications

ASME certified safety valve for each vessel in isolated tubing from vessel.
Process PLC microprocessor
Compressed air pressure 100 psi or 7 bar
Compressed air flow 1 CFH or 28 L/hr

Use this preparative CO2 chromatography system for:

Preparative systems are designed for small to medium volume of raw material. They are used in the pharmaceutical, food supplement and cosmetic industry. They are compact and easy to use. Their dimensions are design to fit any kind of extraction room, ISO8 or ISO7 included. Atomization processes are included in the standard recipe list, together with the CIP cleaning recipe.

They are very flexible and can be adapted to the extraction of many different matrices simply by loading the right recipe. They are robust, designed following the Machine Directive guidelines, perfectly to work 24/7.

Gmp qualifiable

We provide all the necessary documentation requested by qualification inspectors and authority, like:

Material Certificate
Welding Certificate
USR (User Requirement Specifications)
DQ (Design Qualification)
IQ (Installation Qualification)
OQ (Operational Qualification)

Full automation

Automation is a generic term. It does not provide any information on what the machine is really doing on its own. Automation for us is not just the control of pressure, flow or temperature. We have introduced a new concept, “Adaptive Automation”, to describe a new hardware / software system capable of modifying the process cycle as required by the operator. This new automation “literally” changes the way the system will produce the extract, something completely different from simply controlling pressure and temperature.

Remote assistance

We give full support via internet to solve technical problems quickly and for routine maintenance interventions. In many cases our technicians are able to solve problems online without having to physically go to the installation site, by connecting to the system via the internet, thanks to cutting-edge tools for remote support. If it is not technically possible to solve the problem remotely, the technician will be responsible for organizing an intervention on site. All support technicians are qualified and with years of experience.

Design on URS

By User Requirement Specifications we mean the functions that a specific device must have in order to satisfy the needs and requirements of its end user; or, more simply, it is what a device is expected to be able to offer to those who use it, in terms of functionalities. Generally their specification takes place through the drafting of a specific document (called User Requirement Specifications – URS) which takes place in the validation phase of the machinery itself, therefore before this is actually designed.