65 L Near Critical CO2 micronization system NEA

Size & Weight

The frame, the vessels and the piping are built with stainless steel, the total structure has the following characteristics:
Wide 2 m (6.5′), Height 2.1 cm (6,8′), Deep 0.8 m (2.6′).
Weight 220 kg (485#).
Minimum Room size 3×3 m (9.8’×9.8′), Height of 2.3 m (7.4,).

Vessels Volume

Expansion vessel volume: 65 L
Liquid vessel volume: 5 L

System performance

Max pressure: 70 bar
Max temperature: 85° C
Max CO2 flow: 250 kg/h

Main Characteristics

This CO2 micronization system is a production machine equipped with one 65 liter expansion vessel. Stainless-steel frame to comply with HACCP and GMP guide lines. Voltage 120/230V, frequency 60Hz or 50Hz, installed Power 2 kW, Current 10A. Computer on board for automatic process.

NEA technology

In the NEA (Near-critical Expansion Atomization) process, the carbon dioxide is used in this process for the atomization and the crystallization of the product. The product subjected to the process is maintained in the liquid phase in a feed tank at a controlled temperature and subsequently conveyed, at the desired pressure, to the “atomization tower” where there is contact with the carbon dioxide released to atmospheric pressure. The result is the formation of microscopic droplets (atomization) immediately cooled to temperatures much lower than 0° C. The lipid is crystallized in a stable form, and particulate matter obtained has a narrow size distribution in the range 25-100 microns.

The process parameters (carbon dioxide pressure and temperature and product) are regulated automatically in function of the desired particle size. The possibility of working high quantities of product even with very low melting point is an indisputable advantage compared to conventional processes. The direct contact between the product and the carbon dioxide also ensures the optimal exploitation of the properties of cryogenic gas.

Certification

Certifications are mandatory for high pressure equipment. This machine is certified PED/CE for Europe, Africa South America and other countries accepting EU regulation or ASME/UL for North America and other countries requesting ASME regulation.
We are ISO 9001 certified by TUV, UL listed, ASME certified, CE and PED certified by Apave, CRN for Canada.

Configuration of supercritical CO2 micronizer

This machine is designed to work with one CO2 bottle with inner tube and one N2 bottle.

Safety

This system is equipped with two safety relief valves. Improving safety of the operator is our mission.

Other specifications

ASME certified safety valve for each vessel in isolated tubing from vessel.
Process PLC microprocessor
Compressed air pressure 100 psi or 7 bar
Compressed air flow 1 CFH or 28 L/hr

Use this CO2 Micronization system for:

Production machines for micronizatopn are designed to test new lot of material/new matrices micronization for test use or production lots. The utilization of this micronizer also allows to obtain good quantity of micronized powdres or to perform a wide range of productions.

GMP qualifiable

We provide all the necessary documentation requested by qualification inspectors and authority, like:

Material Certificate
Welding Certificate
USR (User Requirement Specifications)
DQ (Design Qualification)
IQ (Installation Qualification)
OQ (Operational Qualification)

Full automation

Automation is a generic term. It does not provide any information on what the machine is really doing on its own. Automation for us is not just the control of pressure, flow or temperature. We have introduced a new concept, “Adaptive Automation”, to describe a new hardware / software system capable of modifying the process cycle as required by the operator. This new automation “literally” changes the way the system will produce the extract, something completely different from simply controlling pressure and temperature.

Remote assistance

We give full support via internet to solve technical problems quickly and for routine maintenance interventions. In many cases our technicians are able to solve problems online without having to physically go to the installation site, by connecting to the system via the internet, thanks to cutting-edge tools for remote support. If it is not technically possible to solve the problem remotely, the technician will be responsible for organizing an intervention on site. All support technicians are qualified and with years of experience.

Design on URS

By User Requirement Specifications we mean the functions that a specific device must have in order to satisfy the needs and requirements of its end user; or, more simply, it is what a device is expected to be able to offer to those who use it, in terms of functionalities. Generally their specification takes place through the drafting of a specific document (called User Requirement Specifications – URS) which takes place in the validation phase of the machinery itself, therefore before this is actually designed.